Synthesis and study of PVDF piezoelectric nanostructure scaffolds with addition of ceramic nanoparticles and biological agents for use in tissue engineering - دانشکده فنی و مهندسی
Synthesis and study of PVDF piezoelectric nanostructure scaffolds with addition of ceramic nanoparticles and biological agents for use in tissue engineering
نوع: Type: Thesis
مقطع: Segment: PHD
عنوان: Title: Synthesis and study of PVDF piezoelectric nanostructure scaffolds with addition of ceramic nanoparticles and biological agents for use in tissue engineering
ارائه دهنده: Provider: Hossein Alibakhshi
اساتید راهنما: Supervisors: Dr. Hamid Esfahani
اساتید مشاور: Advisory Professors: Dr. Esmaeil Sharifi, Dr. Mohammad Reza Ghaani
اساتید ممتحن یا داور: Examining professors or referees: Dr.Morteza Alizade, Dr.Mohsen Sheikhi, Dr.Mehdi Kazazi
زمان و تاریخ ارائه: Time and date of presentation: 2024
مکان ارائه: Place of presentation: سالن کنفرانس
چکیده: Abstract: Treatment of cancer patients with the help of hyperthermia therapy is an effective method. Recently, many efforts have been reported to improve the desirable properties of heating materials of this method. This research deals with the fabrication of nanostructured scaffolds with ferroelectric and ferromagnetic properties using ceramic and polymer materials for the hyperthermia method. Scaffolds were synthesized by electrospinning method with ferroelectric poly(vinylidene fluoride) (PVDF) and in-situ cobalt ferrite oxide (CoFe2O4; CFO) magnetic nanoparticles in the fibers. This research was performed in three steps; 1; Optimizing the electrospinning process to produce a hybrid scaffold, 2; Optimizing the amount of CFO (weight percentage fraction X) in the scaffold for the most favorable hyperthermia properties and 3; Aligning the fibers with the optimal scaffold to improve the hyperthermia behavior. In the first phase, the amount of 15% by weight of PVDF and the electrospinning conditions of 25 kV, 10 cm, and 1 ml/h were optimized to reach 80% of the beta (β) ferroelectric phase. In the second phase, the value of X was changed from 0 to 10 in the fibers and the microstructure, morphology, dielectric, magnetic and piezoelectric properties were investigated. The in-situ formation of CFO was investigated and confirmed by the of X-ray energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD). The results showed that CFO particles were placed inside and or at the junctions of fibers (0 فایل: ّFile:
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